Effect of Sodium Nitrite on the Cerebellar Cortex and Neuro-Protective Effects Of Quercetin

Khattab, Maha Amin Abdallah; Abd El-Baset, Samia Adel; Elsammak, Ghada Abdelaziz; Abdelfattah, Aya Ebrahim

doi:10.21608/zumj.2024.312131.3519

Effect of Sodium Nitrite on the Cerebellar Cortex and Neuro-Protective Effects Of Quercetin

Document Type : Review Articles

Authors

¹ Histology and Cell Biology Department, Faculty of Medicine, Zagazig University, Egypt

² Medical Histology and Cell Biology Department, Faculty of Medicine, Zagazig University, Egypt

³ Medical Histology Department, Fculty of Medicine, Zagazig University, Egypt.

10.21608/zumj.2024.312131.3519

Abstract

Background: Sodium nitrite is a frequently employed food ingredient; however, extended usage at elevated quantities might result in neurological diseases. Inorganic nitrate is regarded as a source of nitric oxide (NO) and nitrite. Sodium Nitrite is frequently used in several industrial processes including fertilizers and food additives. It can prevent food spoilage and act as antimicrobial agent. Nitrite has a significant impact on controlling intricate physiological and biochemical responses, such as reducing inflammation and preventing blood clotting, which are directly linked to the development and management of cerebrovascular illness. Humans can experience overexposure to nitrite salts through different ways. Excessive amounts of nitrite salts can have harmful effects on human and animal health on different systems including the central nervous system (CNS). Conclusion: A recent discovery has revealed the involvement of nitrite in the development of several CNS disorders including the cerebellum. Multiple researches have documented the potential neuroprotective benefits of Quercetin. Quercetin is a naturally occurring flavonoid with bioactive qualities that has recently garnered significant attention for its therapeutic potential in many diseases. The neuroprotective properties of this substance have been proven by numerous in vitro investigations, as well as in vivo animal experiments and human trials. Quinone reductase defends the organism from neurotoxic substances and can also hinder the progression and formation of neuronal damage and neurodegeneration.

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