Serum Uric Acid/ Albumin Ratio and short-term outcomes in ST Elevation Myocardial Infarction

Document Type : Original Article

Authors

1 Professor of Cardiology, Faculty of Medicine, Zagazig University

2 Cardiology Resident at Al-Ahrar Teaching Hospital

3 Assistant Professor of Cardiology, Faculty of Medicine, Zagazig University

Abstract

Background: Serum Albumin (SA) and uric acid (UA) production and excretion could be correlated with major adverse cardiovascular events (MACE) among cases who had ST Elevation Myocardial Infarction (STEMI) and undergone primary Percutaneous Coronary Intervention (PCI). We aimed to assess the relation between high Uric Acid Albumin Ration (UAR) and short-term outcomes among patients who had STEMI and undergone primary PCI

Methods: we carried out this cohort study on 80 patients who had STEMI (and confirmed by cardiac enzymes ECG) divided into two groups: Group I: patients with MACE. (n=33) and Group II: patients without MACE. (n=47), as determined by the modified Dukes criteria. Both groups undergone primary percutaneous intervention. Serum Uric acid, Serum Albumin, and cardiac enzymes (CK, CK-MB, Troponin) were assessed on admission with follow up of cardiac enzymes post procedure.

Results: MACE group had significantly higher uric acid and UAR levels than the non-MACE group (P value <0.01). UAR could significantly predict development of MACE (AUC = 0.65) at cut-off: 1.6 with 81% sensitivity, 76 % specificity. A statistically significant correlation was revealed between the 2 groups in Killip classification (p<0.001), UA, UAR, RWMSI & LVEF (p=0.012, 0.016, 0.002 and 0.014 respectively). Positive correlations were found between Killip Classification, UA, UAR, RWMSI and MACE were revealed (p=0.012, 0.016, and 0.014 respectively) while an inverse relationship between LVEF and MACE was found (p=0.002).

Conclusion: Uric acid-to-albumin ratio could significantly predict development of MACE among patients who had STEMI undergoing PCI with high sensitivity and specificity.

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Zagazig University Medical Journal
Volume 30, Issue 8
November 2024
Pages 4313-4324

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