Serum biomarkers in Alzheimer’s disease

Document Type : Original Article

Authors

1 neurology

2 clinicalpathology department

3 Faculty of medicine, neurology department

Abstract

Abstract

Background:

AD is manifested by a gradually increasing impairment in cognitive functions and neurononal and synaptic loss with presence of senile plaques. Vitamin D has a function in neurotrophy, neurotransmission, neuroprotection, and neuroplasticity, its deficiency share in the pathogenesis of dementia and AD development. Serum albumin is an important human plasma protein and considered as a vital way for amyloid β declaration system as it binds from about 90% to 95% of the amyloid β in the blood.

The goal of this work is to detect if there is a relationship between vitamin D, serum albumin levels in correlation with serum AB and the possibility of AD occurrence. Methods: 64 individuals ,32 patients with dementia and 32 healthy individuals, they were subjected to complete general and neurological examination ,Dementia Severity Rating Scale, MRI brain ,serum vit D ,albumin and AB levels. Results: There is a statistically significance between patients and control groups concerning age, AB42, MMSE, DSRS, serum albumin, and vitamin D. A statistically significant negative correlation between vitamin D and all of age, AB42, and DSRS were found. There is positive correlation between vitamin D and plasma albumin and MMSE. Also there is a positive correlation between plasma albumin and all of vitamin D and MMSE was detected. There is a negative correlation between AB42 and MMSE and statistically positive correlation between AB42 and DSRS.

Conclusion: Low serum albumin and vitamin D levels possibly will increase the possibility of AD dementia.

Keywords

Main Subjects

Zagazig University Medical Journal
Volume 30, Issue 9
December 2024
Pages 4662-4666

Files

Share

How to cite

Statistics