A study of Non-Cultured Epidermal Suspension Grafting Using Trypsinized Epidermal Grafting for Stable Vitiligo

Document Type : Original Article

Authors

1 Professor of Dermatology ,Veneroleogy and Andrology, Faculty of Medicine, Zagazig University, Egypt

2 Dermatology, Venerology & Andrology Department, Faculty of Medicine, Zagazig University, Egypt

3 Professor of Dermatology , Veneroleogy and Andrology, Faculty of Medicine, Zagazig University, Egypt

Abstract

Background: The loss of functioning melanocytes and a dysregulated immune system lead to the persistent depigmenting illness known as vitiligo. The objective of this research was to examine the efficacy of Noncultured epidermal suspension (NCES) transplantation as a therapy for persistent vitiligo. Methods: The investigation was a clinical trial. There were twenty-four patients with stable vitiligo. The degree of repigmentation and color match were assessed 16 weeks after surgery. Results: The percentage of improvement in NCES group, on 8 days, 2 (8.33%) patients had been improved with an improvement percentage of 2%, after 4 weeks 16 (66.67%) patients had been improved with an improvement percentage of 10%, after 8 weeks 14 (58.33%) patients had been improved with an improvement percentage of 30%, after 12 weeks and after 16 weeks, the studied patients showed stable improvement where 12 (50%) patients in both times had been improved with an improvement percentage of 62%. Conclusions: For individuals with stable vitiligo, NCES is the recommended course of treatment due to its great effectiveness. the rate of repigmentation was high in NCES.

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Zagazig University Medical Journal
Volume 31, Issue 1
January 2025
Pages 76-83

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