Cord Blood Metabolic Markers as Mediators of the Effect of Maternal Adiposity on Fetal Growth in Diabetic and Non-diabetic Mothers

Badr, Hytham Reda; Dawoud, Alaa Abdel Sallam; Egiz, Mahy Nabil; Attia, Dina Ahmed; Hamed, Moustafa Bakrey

doi:10.21608/zumj.2024.328414.3641

Cord Blood Metabolic Markers as Mediators of the Effect of Maternal Adiposity on Fetal Growth in Diabetic and Non-diabetic Mothers

Document Type : Original Article

Authors

¹ Internal medicine department, faculty of medicine, Menoufia university, Menoufia, Egypt

² internal medicine department, Faculty of Medicine, Menoufia University, Menoufia, Egypt.

³ Obstetrics and Gynecology department, Faculty of Medicine, Menoufia University, Menoufia, Egypt

⁴ internal medicine department, Faculty of Medicine, Menoufia University, Menoufia, Egypt

⁵ internal medicine department, faculty of medicine, menoufia university, Menoufia, Egypt

10.21608/zumj.2024.328414.3641

Abstract

BACKGROUND; Obesity and Type2 diabetes (T2DM) have multiple complications may be related to insulin resistance (IR). T2DM is widely spreading disease among pregnant women. Unfavorable perinatal outcomes have to occur in obese diabetic mothers. The aim of this work was to analyze the link between maternal obesity and neonatal anthropometric results, as well as the link between cord blood metabolic indicators and the fetal overgrowth.

METHODS: 140 pregnant women were included at Menoufia University Hospital in prenatal and postpartum phases. All participants were divided into four equal groups: group (1) obese, diabetic, group (2) obese non diabetic, group (3) non obese diabetic and group (4) was non obese non diabetic. All patients subjected to full history taking, anthropometric measures (weight and height), clinical assessment and laboratory investigations including (C-peptide, triglycerides, HDL, Random blood sugar).

RESULTS: Obese patients had higher significant mean serum c-peptide level. It was shown to be responsible for 18% (95 percent) confidence interval of the link between maternal body mass index (BMI) and large for Gestational age (LGA). Regarding fetal outcomes, diabetic patients have a higher significant LGA.

Diabetic patient has higher statistically significant difference of CRP P=(0.001) rather than non-diabetic.

Regarding HDL obese patient have higher significant differences than other groups.

CONCLUSION: Pregnant women with Gestational Diabetes Mellitus, and T2DM all had higher C-peptide levels in their baby's blood than women with normal glucose tolerance.

Keywords