Diagnostic Value Of Matrix Metalloproteinase-2 In Children With Refractory Epilepsy

Document Type : Original Article

Authors

1 Pediatrics Department, Faculty of Medicine, Zagazig University

2 Clinical pathology Department, Faculty of Medicine, Zagazig University

3 Pediatrics Department, Faculty of Medicine, Zagazig University, Egypt

Abstract

Background: Epilepsy is a common neurological condition that causes disruptions in the brain's electrical activity for a number of reasons. Resistant epilepsy is an uncontrollable seizures in spite of two well-toierated, suitably chosen antiepileptic medications (AEDs) given either in combination or as monotherapies. This is the first investigation at Zagazig University Hospitals to find out if refractory epilepsy and Matrix Metalloproteinase-2 are related. The purpose of this study is to evaluate the diagnostic utility of Matrix Metalloproteinase-2 in children receiving treatment at Zagazig University Hospitals for refractory epilepsy.

Methods: Forty three children with refractory epilepsy and Forty three healthy children were examined for Matrix Metalloproteinase-2 by Enzyme Linked Immunosorbent Assay (ELISA).

Results: The mean MMP-2 concentration exhibited a substantial decrease in the patient group compared to the control group, with a highly significant p-value of <0.001.

Conclusion: This study supports that MMP-2 could play a crucial role in timely and precise clinical interventions for children with refractory epilepsy.

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Zagazig University Medical Journal
Volume 31, Issue 2
February 2025
Pages 601-612

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