Association Between BAFF Gene Polymorphism And Clinical course of Newly Diagnosed Immune Thrombocytopenic Purpura In Children

Document Type : Original Article

Authors

1 Pediatric department, faculty of Medicine, Zagzig University

2 pediatric department, faculity of medicine, Zagazig university

3 pediatric department, faculity of medicine, zagazig university

4 biochemistry department, faculity of medicine, zagazig university

Abstract

Background : Primary immune thrombocytopenia is an autoimmune disorder characterized by autoantibody-mediated enhanced platelet destruction. BAFF gene polymorphisms increases BAFF expression and antibody production in ITP patients, which causes platelet destruction and megakaryopoiesis suppression
Objective: To study the frequency of BAFF gene polymorphisms in newly diagnosed ITP in children and their association with it's clinical features and course.
Methods: A case control study was conducted at Hematology Unit of pediatric department and Medical Biochemistry &Molecular Biology department at Zagazig University Hospital during a period from Nov. 2017 until Nov. 2018.The study Included 40 patients with newly diagnosed ITP (25 males and 15 females) and 20 age and sex-matched healthy children (11males and 9 females) as a control group. All children were subjected to a detailed medical history ,thorough clinical examination and Laboratory investigations including CBC , BM aspiration and B cell activating factor gene polymorphism (-871C/T) detection by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
Results: There was also a highly significant difference between ITP cases and control regarding distribution of SNP of BAFF gene where CT was founded in 55% of ITP cases versus 25% in control; also, CC was
founded in 75% of control versus 20% of cases. There was non-significant difference between different subtypes
of BAFF gene polymorphism regarding age, gender, initial bleeding events,CBC, type of treatment and outcome of ITP cases.
Conclusion: Significant association of BAFF gene polymorphism with newly diagnosed immune thrombocytopenic purpura in children may indicate its possible role in disease pathogenesis.

Keywords

Zagazig University Medical Journal
Volume 26, Issue 1 - Serial Number 1
Medicine - Pediatrics - Laboratory Medicine
January and February 2020
Pages 165-173

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