Serum Endocan Levels in Patients with Psoriasis Vulgaris as a Marker of Disease Severity

Document Type : Original Article

Authors

1 Dermatology,venereology&Andrology Department,Faculty of Medicine,Zagazig University,Zagazig,Egypt

2 Department of Clinical Pathology,Faculty of Medicine,Zagazig University,Zagazig, Egypt

3 Dermatology,Venereology&Andrology Department, Faculty of Medicine, Zagazig University,Zagazig,Egypt

4 Dermatology, Venereology & Andrology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Abstract

ABSTRACT
Background: Endocan is a specific molecule of human endothelial cell. It was accepted as a marker of endothelial dysfunction that is widely involved in psoriasis development. Our aim was to evaluate the relation between serum endocan levels and severity of psoriasis vulgaris .
Methods: Twenty-two patients with psoriasis vulgaris were involved . We measured serum endocan, c-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Psoriasis severity was evaluated by Psoriasis Area and Severity Index (PASI) score.
Results: The mean serum level of endocan was 154±49.3 pg/ml with a range from 59 to 210 pg/ml. Its level was statistically significant increase in moderate and severe psoriatic patients compared to mild psoriatic patients. No statistically significant correlations were detected between serum endocan and CRP (P=0.11) and ESR(P=0.16). In contrast, a very highly statistically significant positive correlation was detected between endocan and disease severity(p=0.001).
Conclusions: Serum endocan can be a promising marker that correlates with psoriasis vulgaris severity.

Keywords

Zagazig University Medical Journal
Volume 26, Issue 3
Pediatrics,Cardiology,Internal Medicine,Community Medicine,Chest,Rheumatology,Dermatology&Psychiatry
May 2020
Pages 517-523

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