The relationship between Adiponectin and Serum Oxidative Stress factors in Parkinson's Disease

Document Type : Original Article

Authors

1 neurology department, faculty of medicine , zagazig university

2 clinicalpathology department, faculty of medicine , zagazig university

Abstract

Abstract

Background: Parkinson's disease [PD] is a common neurodegenerative disease. Oxidatant stress factors are a main cause in the pathogenesis of PD.

Our study aimed to estimate the relations between serum levels of vitamin C, ferritin, transferrin, Nitrite Oxide [NOx] and Adiponectin in correlation with parkinsonian severity.

Methods: a case control study done on27 PD patients and 27 healthy subjects, measuring serum vitamin C, ferritin, transferrin, Nitrite Oxide [NOx] and Adiponectin levels with UNIFIED PARKINSON'S DISEASE RATING SCALE (UPDRS) was done to detect parkinsonian severity in the patients.

Results: there is a significant difference between the two studied groups regarding age, NOx, vitamin C, and ferritin level. There is also significant difference between the patients and control groups regarding Adiponectin level [it is significantly higher among case group].

The cutoff point of serum Adiponectin in diagnosis of Parkinsonism is ≥12.115 μg/mL and the area under curve was 0.866, sensitivity 92.6%, specificity 81.5%, the value of positive prediction was 83.3%, negative predictive was 91.7% and overall accurateness was 87%.there were a positive correlation between Adiponectin and NOx, UPDRS and ferritin among case group.

Conclusion: Serum levels of vit C, ferritin ,NOx and Adiponectin are significantly higher in patients with PD. In addition, it can be suggested that to have a role in progression of PD. More researches are needed on more patients and different ethnics to afford more data about the disease severity and the outcome.

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Zagazig University Medical Journal
Volume 31, Issue 6
June 2025
Pages 2256-2262

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