Anhedonia in Relatives of Schizophrenic Patients

Document Type : Review Articles

Authors

1 Assistant Professor of Psychiatry, Faculty of Medicine, Zagazig University, Egypt

2 Professor of Psychiatry, Faculty of Medicine, Zagazig University, Egypt

3 Department of Psychiatry, Faculty of Medicine, Zagazig University, Egypt

4 Lecture of Psychiatry, Faculty of Medicine, Zagazig University, Egypt

Abstract

Background: A serious mental condition with a wide range of intricate symptoms is schizophrenia. It has resulted in a significant healthcare burden and affects approximately 1% of the population. Since schizophrenia is a disorder that relapses quickly, it is recommended that patients receive long-term treatment. There was a notable family aggregation of schizophrenia in the risk of schizophrenia among first-degree relatives (FDR, siblings, and kids). In monozygotic twins, the susceptibility to schizophrenia was more markedly heritable. Patients with FDR of schizophrenia are ten times more likely to develop schizophrenia than the general population. Nonetheless, research has demonstrated that individuals with FDR who subsequently developed schizophrenia display abnormalities in brain structure, function, and neurochemical properties before the onset of schizophrenia. This suggests that some of the abnormalities in schizophrenia may also be present in FDR and could serve as risk factors for schizophrenia development. This review's goal was to assess the results of some genetic high risk (GHR) and family high risk (FHR) studies on the FDR of individuals with schizophrenia, which revealed that these individuals had significant or moderate neurocognitive abnormalities. Anhedonia in family members of people with schizophrenia. Conclusion: It was found that relatives of schizophrenic patients are at high risk of developing physical anhedonia than normal population which may be used as a useful indicator of liability for schizophrenia among the relatives of affected population

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Zagazig University Medical Journal
Volume 31, Issue 4
April 2025
Pages 1538-1542

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