Effect of Short Period Administration of Inositol and Metformin on Hormonal and Lipid Profile in Women with Polycystic Ovary Syndrome

Shazly, Sherin Attia; Zidan, Amal Ahmed; Gomaa, Doaa Abdallah Abdelrahman; Abd Alsalam, Hoda Sibai

doi:10.21608/zumj.2025.364005.3857

Effect of Short Period Administration of Inositol and Metformin on Hormonal and Lipid Profile in Women with Polycystic Ovary Syndrome

Document Type : Original Article

Authors

¹ Obstetrics and Gynecology Department, Faculty of Medicine, Zagazig University, Egypt

² Clinical pathology Department, Faculty of Medicine, Zagazig University

³ Obstetrics &amp;amp; Gynecology Department, Faculty of Medicine, Zagazig University

⁴ Obstetrics & Gynecology Department, Faculty of Medicine, Zagazig University

10.21608/zumj.2025.364005.3857

Abstract

Background: It has been difficult to diagnose and treat polycystic ovarian syndrome (PCOS). Because it functions as an insulin sensitizer, metformin plays a significant role in the treatment of PCOS. It has been found that inositol, a new natural chemical, affects PCOS hormones. Therefore, our goal was to assess the effects of metformin, inositol, or both on the lipid and hormonal profiles of women with PCOS.

Methods: This study was carried out in department of obstetrics & gynecology in Zagazig university hospitals on patients with PCOS. Patients were divided into: Group 1: received inositol. Group 2: received metformin. Group 3: received inositol and metformin.

Results: Regarding oligomenorrhea, amenorrhea and acne, there was no significant difference before and after treatment in the three studied groups while there was significant improvement after treatment in each group, regarding hirsutism score there was significant decreased in group3 than group 1 and group 2. There was a significant difference regarding cholesterol that was lower in group 1 than group 2 and group 3 and HDL that was higher in group 3 than group 1 and group 3. There was a significant decrease in FSH and LH after treatment in group 1, group 2 and group 3 .

Conclusion: Both metformine and inositol have a positive impact on PCOS symptoms and test findings. However, combining the two produced superior outcomes.

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