Dosimetric Study of Acute Dysphagia in Patients with Laryngeal Carcinoma Irradiation

Document Type : Original Article

Authors

Clinical Oncology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Abstract

Background: Dysphagia has been reported in up to 28% in head and neck carcinoma. Dysphagia results from acute tissue injury that causes mucosal damage, edema, and neuromuscular dysfunction . Neurogenic dysfunction contributes to the development of dysphagia brought on by radiation. Aspiration can occur up to 68% of the time after chemo-radiation for head and neck carcinoma. Aim :To improve treatment outcome in head and neck carcinoma.

Study design: A prospective cohort research., involved 36 patients diagnosed by Head and neck squamous cell carcinoma. The patients received radiotherapy ± chemotherapy. The study focused on the predictors of acute dysphagia.

Results: Higher mean doses to superior constrictor muscle( SCM), middle constrictor muscle( MCM), and inferior constrictor muscle (ICM )were associated with higher odds of developing Grade III dysphagia: SCM mean (Gy): 1.5 times (95% CI: 1.16-1.90),MCM mean (Gy): 1.2 times (95% CI: 1.05-1.39),ICM mean (Gy): 1.4 times (95% CI: 1.1-1.77).

Conclusion: elevated mean doses to (SCM), (MCM), (ICM), and esophagus were significant predictive factors for severe dysphagia.

Key words: Neck, Carcinoma, Irradiation, Dosimetric and Dysphagia.

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Zagazig University Medical Journal
Volume 31, Issue 7
July 2025
Pages 2695-2707

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