Role of Galectin-3 on Left Atrial Deformation Relation to Exercise Tolerance in Patients with Mild Mitral Stenosis

Document Type : Original Article

Authors

1 Cardiology Department, Faculty of Medicine, Zagazig University

2 cardiology department , Zagazig University

3 cardiology department , Zagazig University , Zagazig

Abstract

Background: Despite the rheumatic fever is becoming less common, rheumatic MS continues to be a major cause of morbidity and death in underdeveloped nationsAim: We aimed to investigate the influence of Galectin-3 (Gal-3) as a fibrotic marker on left atrial strain and its potential association with reduced exercise tolerance in patients with mild rheumatic mitral stenosis..Methods: We performed evaluation of left strain in patients with mild MS using two-D speckle tracking imaging. Also, left and right ventricular strain was performed. All participants performed experience exercise based on Bruce protocol. Galectin-3 concentration was obtained with ELISA. serum.Results: 87 patient with mild MS were recruited. Compared with controls, those with mild MS had a higher value of Gal-3 Lower left atrial reservoir (LAS-S) (P<0.001). Additionally, in patients with poor exercise tolerance, exercise dramatically reduced both the longitudinal strain of the left ventricle and the longitudinal strain of the right ventricle's free wall. (P<0.03). LAS-Swas negatively correlated with Gal-3 concentration (P<0.001). Results revealed that LAS-S, reduced LVLGS%, reduced RVFWLS% and Gal-3 were independent predictors for reduced exercise tolerance in patients with mild MS. Importantly, ROC curve analysis revealed that LAS-S ≤17.3 was the best cut-off value to predict reduced exercise tolerance, whilst, Gal-3 value ≥ 19.95 ng/ml was cut-off value for prediction of reduced LAS-S ≤17.3 in patients with mild MS

Conclusions: Galectin-3 was an independent predictor of a reduced percentage of LA strains in patients with mild MS. Furthermore, there was a significant association between LAS-S and reduced exercise tolerance.

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Zagazig University Medical Journal
Volume 31, Issue 6
June 2025
Pages 2335-2345

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