Background: Cerebral ischemia initiates an inflammatory response in the brain which is a composite process that involves many inflammatory mediators.The investigation of inflammatory response in the acute stage may contribute to improve the treatment of ischemic stroke. Objective: We assessed the relationship between peak values of serum interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1),erythrocyte sedimentation rate (ESR), c-reactive protein (CRP)and nitric oxide (NO)in the first week after ischemic stroke, with measures of stroke severity and outcome.Methods:forty-five patients (22 males and 23 females) with ischemic stroke were prospectively recruited. Serum IL-6, and other markers of peripheral inflammation, was measured at time points 24 h, as well 7 days after symptom onset.Twenty-five age-matched volunteers were used as controls. We correlated levels with stroke severity assessed by the NIH Stroke Scale; stroke outcome at 1 month assessed by BI and computed tomography (CT) brain infarct volume. Result(s): Peak serum IL-6 and CRP concentrations correlated significantly (p < 0.001) with CT brain infarct volume (r = 0.75) and NIHSS at 1 week (r = 0.72). They correlated similarly with clinical outcome at 1 month. Strong associations were also noted between either peak serum ICAM-1 or NO concentrations and short-term stroke outcome. Conclusion(s):These data provide evidence that the peripheral inflammatory response may be related to the severity of acute ischemic stroke, and may be used as predictors for clinical outcome.
SMA, E., EA, A., HM, O., & TH, E. (2014). ASSESSMENT OF THE SERUM INTERLEUKIN-6, INTERCELLULAR ADHESION MOLECULE-1, NITRIC OXIDE AND C-REACTIVE PROTEIN IN ACUTE ISCHEMIC STROKE. Zagazig University Medical Journal, 20(4), 1-9. doi: 10.21608/zumj.2014.4405
MLA
El-Shazly SMA; Abdel-Gawad EA; Omar HM; El-Khatib TH. "ASSESSMENT OF THE SERUM INTERLEUKIN-6, INTERCELLULAR ADHESION MOLECULE-1, NITRIC OXIDE AND C-REACTIVE PROTEIN IN ACUTE ISCHEMIC STROKE". Zagazig University Medical Journal, 20, 4, 2014, 1-9. doi: 10.21608/zumj.2014.4405
HARVARD
SMA, E., EA, A., HM, O., TH, E. (2014). 'ASSESSMENT OF THE SERUM INTERLEUKIN-6, INTERCELLULAR ADHESION MOLECULE-1, NITRIC OXIDE AND C-REACTIVE PROTEIN IN ACUTE ISCHEMIC STROKE', Zagazig University Medical Journal, 20(4), pp. 1-9. doi: 10.21608/zumj.2014.4405
VANCOUVER
SMA, E., EA, A., HM, O., TH, E. ASSESSMENT OF THE SERUM INTERLEUKIN-6, INTERCELLULAR ADHESION MOLECULE-1, NITRIC OXIDE AND C-REACTIVE PROTEIN IN ACUTE ISCHEMIC STROKE. Zagazig University Medical Journal, 2014; 20(4): 1-9. doi: 10.21608/zumj.2014.4405
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