Relationship Between H2FPEF and SYNTAX Scores in Patients with Chronic Stable Angina

Document Type : Original Article

Authors

1 Cardiology Department, Faculty of Medicine, Zagazig University, Egypt

2 Cardiology Department, Banha Teaching Hospital, (GOTHI), Egypt

Abstract

Background: Both ischemic heart disease and heart failure with preserved ejection fraction (HFpEF) share common metabolic risk factors such as obesity and hypertension. The H₂FPEF score assesses the likelihood of HFpEF, while the SYNTAX score evaluates the severity of coronary artery disease in patients with chronic stable angina. Recent studies suggest a correlation between elevated H₂FPEF and SYNTAX scores, indicating overlapping pathophysiological mechanisms like microvascular dysfunction and myocardial stiffness. This relationship may support earlier detection of HFpEF and guide more personalized treatment strategies. Therefore, our goal was to find out how H2FPEF and SYNTAX scores relate to each other in individuals with chronic stable angina.

Methods: This cross-sectional observational study was carried out at Benha Teaching Hospital and Zagazig University Hospitals' Cardiology Department on 67 individuals presenting with chronic stable angina. In every cases, the H₂FPEF score was calculated.

Results: Patients with higher H2FPEF scores demonstrated significantly elevated echocardiographic parameters such as E/e′ ratio, TR max.v, and ESPAP. Further confirming the H2FPEF score's predictive accuracy were correlation and ROC analyses, surpassing traditional measures like EF%.

Conclusion: In patients having coronary angiography for chronic stable angina, the H2FPEF score is a reliable indicator of the severity of coronary artery disease, as determined by the SYNTAX Score I.

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Zagazig University Medical Journal
Volume 31, Issue 9
September 2025
Pages 4499-4514

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