Document Type : Original Article
Authors
1
Professor of Pediatrics Department, Faculty of Medicine, Zagazig university, Egypt
2
Professor of Biochemistry Department, Faculty of Medicine, Zagazig University, Egypt
3
Pediatrics Department, Faculty of Medicine, Zagazig University, Egypt
4
Lecturer of Pediatrics Department, Faculty of Medicine, Zagazig university, Egypt
Abstract
Background: Chronic kidney disease (CKD) is a major, prevalent, and serious public health issue, and its prevalence is increasing around the world. Plasma cystatin C (Cys C) is a measure for evaluating kidney function. Its usefulness in assessing whether hemodialysis (HD) is suitable for patients with end-stage renal disease has not been conclusively shown. The study aimed to assess Cys C and serum creatinine (SCr) levels in CKD children pre- and post-HD, and to evaluate the effectiveness of serum Cys C determination in cases experiencing low-flux HD.
Methods: This Cohort study was performed in the pediatrics nephrology unit at Zagazig University children hospitals. All patients of the studied groups were subjected to: Full history taking, history of any associated diseases, time of diagnosis and first hemodialysis, frequency of hemodialysis per week, and drug therapy. In addition, complete physical examination including assessment of general condition, vital signs, and laboratory tests (Complete blood picture, Serum urea, creatinine, Serum albumin, bilirubin, AST, ALT, Serum electrolytes, Cys C, Serum urea and, SCr).
Results: There was significant reduction in serum levels of urea, and creatinine after hemodialysis as compared to before-dialysis. There was statistically significant elevation in Cys C level after dialysis as compared to before dialysis.
Conclusion: Cystatin C is an alternative endogenous marker of kidney function that is unaffected by muscle mass, or protein consumption, as well as by sex and age. It rises rapid than creatinine, allowing for earlier identification of illness.
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