Correlation between glycemic gap and short-term adverse outcome in diabetic patients undergoing elective PCI

Zein ELabdeen, Shimaa Gamal; Moustafa, Tamer; Alazzawy, Ahmed Yehia; Abomandour, Hala Gouda

doi:10.21608/zumj.2025.393803.3997

Correlation between glycemic gap and short-term adverse outcome in diabetic patients undergoing elective PCI

Document Type : Original Article

Authors

¹ Cardiology Department, Faculty of Medicine, Zagazig University

² Cardiology Department. Faculty of Medicine, Zagazig University. 44519. Egypt.

³ Cardiology resident , cardiology department , Zagazig Chest Hospital. Egypt .

10.21608/zumj.2025.393803.3997

Abstract

Background: Acute hyperglycemia is a common finding in patients presented to the emergency department. The prognostic role of hyperglycemia in non-diabetic patients with (ACS) may be well established, compared to diabetic patients in whom it remains controversial. We aimed to evaluate the correlation between the glycemic gap and adverse coronary vascular events in diabetic patients undergoing elective percutaneous coronary intervention (PCI).

Patients and Methods: a cross-sectional study that was conducted on 140 diabetic patients undergone elective PCI, patients were classified according to the glycemic gab in to: Group (1): patients with glycemic gap ≥42 mg/dl, Group (2): Patients with glycemic gap < 42 mg/dl. All participants followed up for one year for possible coronary complications and MACE development.

Results: Our results showed that there are no statistically significant differences between the two groups in terms of the affected coronary arteries. Group I had a significantly longer hospital stay, higher incidence of major adverse cardiac events, ICU admissions, in-stent restenosis, in-stent thrombosis, and mortality rates. Glycemic gap can significantly predict MACEs in T2DM patients who underwent elective PCI (AUC= 0.615, P value =0.035) at cut off 42 mg/dl, 69.70% sensitivity, 54.21% specificity, 31.9% PPV and 85.3% NPV.

Conclusions: Glycemic gap is a simple method that can be applied easily to all diabetic patients who undergo elective PCI, to predict the short term cardiovascular adverse outcome and so should be tightly controlled before elective PCI.

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