Assessment of Kidney Status in Cardiac Children Treated with Angiotensin Converting Enzyme Inhibitors

Document Type : Original Article

Authors

1 pediatrics, faculty of medicine, zagazig university Postal Code: 44519 info@zu.edu.eg : E-MailAddress:Zagazig - Zagazig UniversitySharkia - Egypt

2 pediatric nephrology unit , zagazig university, Egypt Postal Code: 44519 info@zu.edu.eg : E-MailAddress:Zagazig - Zagazig UniversitySharkia - Egypt

3 pediatric department Postal Code: 44519 info@zu.edu.eg : E-MailAddress:Zagazig - Zagazig UniversitySharkia - Egypt

4 pedaitric departemnt Postal Code: 44519 info@zu.edu.eg : E-MailAddress:Zagazig - Zagazig UniversitySharkia - Egypt

Abstract

Background: Angiotensin Converting Enzyme Inhibitors (ACEIs) are commonly used to treat many cases especially chronic heart failure and there is different data about kidney affection in those patients, we aimed in this study to evaluate the kidney status in patients using this medication weather on chronic bases or recently added.
Patients and methods: We studied 50 cardiac children 15 of them with old treatment with ACEIs group A, 15 of them with new treatment with ACEIs group B and 20 of them not use ACEIs as a control group as group C, all patients were subjected to detailed history taking including demographic data, Glomerular filtration rate calculated For children by modified Schwartz method in addition to Routine test of kidney function.
Results: There was statistically significant higher creatinine level and lower eGFR in group A and B than control group, there was 40% of patients on old ACEIs treatment suffered from metabolic acidosis and increased creatinine level in blood compared to (10% and 20% among group B, 5% and 0% among group C respectively), while 50% of group A suffered of hyperkalemia and decreased GFR versus 20% among group B and 5% among group C respectively, and the difference between groups was statistically significant. There was a statistically significant negative correlation between duration using ACEIs and GFR and urine output,
Conclusion: We concluded that there is high risk of renal impairment in cardiac children treated with ACEIs and this risk is higher with increasing duration of therapy with these drugs

Keywords

Zagazig University Medical Journal
Volume 26, Issue 3
Pediatrics,Cardiology,Internal Medicine,Community Medicine,Chest,Rheumatology,Dermatology&Psychiatry
May 2020
Pages 414-422

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