Assessment of copeptin levels in children with type 1 diabetes

Document Type : Original Article

Authors

1 Pediatrics department, Faculty of Medicine, Zagazig university

2 pediatrics department, faculty of medicine, zagazig university

3 Clinical Pathology Department, Zagazig University Hospitals, Zagazig, Egypt

Abstract

Abstract
Background: Children with type 1 diabetes are in risk of developing renal complications as a part of microvascular complications on the long run, early diagnosis of these complications can decrease morbidity and mortality of these complications. Copeptin has shown association with development of chronic kidney disease (CKD) in people with diabetes.
Methods: This is a case - control study was conducted at Zagazig University Hospital of pediatrics from June 2017 to January 2018 on 40 cases suffering from T1DM. It also included 40 matched healthy controls who attend outpatient clinics for routine care.
All cases were subjected to a complete clinical study (thorough history and physical examination) upon study inclusion, with emphasis on symptoms and signs of diabetes and renal affection.
The following investigations were performed: HbA1c, Urine analysis, Albumin/creatinine ratio, renal function test (creatinine, BUN) Renal Ultrasound, Measure serum copeptin level by ELISA (Sandwich technique).
Results: Our study showed that there is a significant increase in serum copeptin levels compared to healthy group. There is no significant difference between poorly controlled and well controlled children with T1DM regarding copeptin levels. Serum copeptin has also a positive correlation with albumin/creatinine ratio in children with T1DM.

Conclusion: Serum copeptin is a potential prognostic biomarker in childhood diabetic renal affection.

Keywords

Zagazig University Medical Journal
Volume 26, Issue 3
Pediatrics,Cardiology,Internal Medicine,Community Medicine,Chest,Rheumatology,Dermatology&Psychiatry
May 2020
Pages 397-404

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