Assessing Myocardial Ischemia Using Troponin I as a Diagnostic Marker with Electrocardiography Prior to and After Paediatric Cardiac Catheterization

EL-Hindawy, Eman Mohammed; Khalil, Azaa Ali; Ali Elanani, Sara Hassan; Abdel-Wehab, Lamiaa Abdelaziz; Abdelbar, Ahmed Tarek; Ahmed, Amani Abdelaziz

doi:10.21608/zumj.2025.406274.4066

Assessing Myocardial Ischemia Using Troponin I as a Diagnostic Marker with Electrocardiography Prior to and After Paediatric Cardiac Catheterization

Document Type : Original Article

Authors

¹ Pediatric departmen ,faculty of medicine,Zagazig university

² Department of Pediatric,Faculty of Medicine –ZagazigUniversity,Egypt.

³ Pediatric resident at Abu Hammad central hospital

⁴ Department of Clinical Pathology, Faculty of Medicine - Zagazig University, Egypt

⁵ internship ,faculty of medicine , zagazig university

⁶ pediatric department ,faculty of medicine ,Zagazig university

10.21608/zumj.2025.406274.4066

Abstract

Background: High-sensitivity cardiac troponin I (hs-cTnI) is a sensitive and specific marker for identifying myocardial damage and releases from the cardiac muscles during cardiac catheterization. So, we aimed to assess serum (hs-cTnI) level with electrocardiograph (ECG) monitoring in children before and 12 hours after catheterization to correlate its level, ECG changes and myocardial injury.

Methods: Twenty-five pediatric patients participated in this prospective cohort study, which was conducted at Zagazig University Hospitals, Pediatric Cardiac Catheterization Unit. Detailed history taking, clinical examination, biochemical, and radiological profiles were evaluated. High sensitivity cardiac troponin I and ECG were assessed before and 12 hours after cardiac catheterization.

Results: After catheterization, troponin I levels increased from 0.113±0.01 ng/mL to 0.131±0.02 ng/mL, a statistically significant rise. Troponin I levels rose significantly from 0.110±0.02 to 0.151±0.02 post-catheterization for patients with interventional pulmonary stenosis, but there was no statistically significant difference in mean levels between those who had the intervention procedure for atrial septal defect and patent ductus arteriosus before and after. There were no notable post-procedural signs of ischemia detected by ECG monitoring.

Conclusion:

Pediatric cardiac catheterization appears to be safe and well-tolerated procedure with minimal risk of inflammatory, hematologic, or electrophysiological complications. Troponin I proved to be a sensitive biomarker for detecting subclinical myocardial stress, even in the absence of clinical or ECG findings. The overall findings reinforce the value of catheterization in both diagnosis and treatment of congenital heart defects and support its continued use in pediatric cardiology with careful monitoring and patient selection.

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