Effectiveness of Platelet-Rich Plasma in the Management of Chronic Diabetic Foot Ulcers.

Salim, Ayman Abdelhamid; Tawfik, Ahmed Mohammed; Mohammed Abdelghany, Khalid Mohammed; Ellithy Soliman, Mahmoud Ali

doi:10.21608/zumj.2025.413066.4101

Effectiveness of Platelet-Rich Plasma in the Management of Chronic Diabetic Foot Ulcers.

Document Type : Original Article

Authors

¹ Professor of Vascular Surgery, Faculty of Medicine, Zagazig University, Egypt.

² Professor of Vascular Surgery, Faculty of Medicine, Zagazig University, Egypt

³ Department of vascular Surgery, Faculty of Medicine, Zagazig University, Egypt

⁴ Assistant Professor of Vascular Surgery, Faculty of Medicine, Zagazig University, Egypt

10.21608/zumj.2025.413066.4101

Abstract

Background: Diabetic foot ulcers (DFUs) are a dangerous side effect of diabetes that often leads to infection and amputation. Platelet-rich plasma (PRP) therapy is one promising strategy to enhance wound healing. This study aimed to evaluate the effectiveness of platelet-rich plasma (PRP) in treating chronic diabetic foot ulcers. Methods: This randomized controlled clinical trial was conducted at the Vascular Surgery Department, Zagazig University Hospitals, and included Eighty patients with chronic DFUs were randomly assigned into two groups: PRP treatment group (n=40) and conventional dressing group (n=40). Patients were followed for 12 weeks, and ulcer healing parameters including healing area, rate of complete healing, and laboratory values were assessed. Results: The PRP group demonstrated significantly larger healing areas at all follow-up points (p=0.01) and faster complete healing rates, with 70% achieving full healing by week 12 compared to 47.5% in the conventional group (p=0.01). Laboratory parameters including Hb, PLT, albumin, and HbA1c were comparable between groups. No adverse effects were reported. Conclusion: In addition to its defensive function, which lowers amputation rates, platelet-rich plasma (PRP) is a popular defense for healing chronic ulcers and reducing infection rates. For this reason, PRP is regarded as a very effective method for treating chronic ulcers, particularly diabetic foot wounds.

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