Comparative Study of Intensity Modulated Radiotherapy, Volumetric Modulated Arc Therapy versus Three Dimensional Radiotherapy in High Grade Glioma Patients

Document Type : Original Article

Authors

1 Clinical OncologyDepartment, Faculty of Medicine, Zagazig University, Zagazig, Egypt

2 Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

3 clinical oncology and nuclear medicine department,faculty of medicine,zagazig university

4 Clinical Oncology and Nuclear Medicine department, Faculty of Medicine, Zagazig University Zagazig, Egypt.

5 Assistant professor of clinical oncology,Zagazig University, Al sharkia

Abstract

Back ground: In contrast to three-dimensional conformal radiotherapy (3DCRT), intensity-modulated radiotherapy (IMRT) improves dose homogeneity, conformity, and target volume coverage while delivering less radiation to normal brain tissue and organs at risk , such as the brainstem, optic nerves, optic chiasm, and brainstem. VMAT is an advanced radiation therapy method that administers radiation continuously while the treatment machine rotates around the patients.

Methods: Planning data from 48 patients with high-grade glioma (HGG) were analyzed. The dose distribution for the CTV, PTV, and OAR was compared across three techniques—3D CRT, IMRT, and VMAT—using Dose Volume Histograms (DVHs)



Results: We found the PTV coverage in terms of V95% was significantly higher in the VMAT and IMRT plans with values of 99.93 ± 0.12 and 99.49± 0.61 respectively compared to 98.23 ± 0.64 for the 3D-CRT plans





Conclusion: the VMAT technique has proven better capability in reducing the radiation exposure to nearby healthy organs .



Key words:3DCRT,IMRT,VMAT and HGG.

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Zagazig University Medical Journal
Volume 31, Issue 10
October 2025
Pages 4974-4983

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