Triglyceride-Glucose Index as an Indicator for Early Prediction and Progression of Chronic kidney Disease in Hypertension Patients

Mohamed, Ezzat Mostafa; Hassan, Sara Mohammed; Elsayed, Fatma M. Attia; Ibrahim, Fatma Atef; Kamel, Reda Abd Elmoniem

doi:10.21608/zumj.2025.406108.4063

Triglyceride-Glucose Index as an Indicator for Early Prediction and Progression of Chronic kidney Disease in Hypertension Patients

Document Type : Original Article

Authors

¹ Professor of Internal Medicine Department, Faculty of Medicine, Zagazig University, Egypt

² Internal Medicine Department, Faculty of Medicine, Zagazig University, Egypt

³ Lecturer of Internal Medicine Department, Faculty of Medicine, Zagazig University, Egypt

⁴ Lecturer of Clinical Pathology Department, Faculty of Medicine, Zagazig University, Egypt

⁵ Assistant Professor of Internal Medicine Department, Faculty of Medicine, Zagazig University, Egypt

10.21608/zumj.2025.406108.4063

Abstract

Background: In order to apply evidence-based therapies that can prevent the progression of chronic kidney disease (CKD) to advanced stages, routine screening in hypertensive individuals is essential at the time of diagnosis. This study aim to early prediction and monitoring of progression of CKD in hypertensive patients using Triglyceride-Glucose Index (TyG index). Methods: This retrospective case control study included 85 hypertensive patients with CKD and a similar number of hypertensive patients without CKD. The patients data were followed up for 6 months, eGFR and TyG index were evaluated. Results: Patients without CKD had considerably lower diastolic blood pressure than those with CKD. Patients without CKD experienced a considerably shorter mean duration of hypertensive than individuals without CKD. CKD patients had lower HDL and greater cholesterol. Compared to patients with CKD, those without CKD had a much higher eGFR. Patients with CKD had a considerably higher TyG index level than individuals without CKD. TyG index demonstrated 100% sensitivity and accuracy in predicting CKD in hypertension patients, and its diagnostic performance in predicting CKD in hypertensive patients at cutoff was greater than 8.91. Conclusion: TyG index is a useful biomarker for the prediction of CKD in hypertensive patients and identifying individuals who are at risk of CKD.

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