Clinical outcomes of Tranexamic acid administration in Elective Cesarean Delivery :-Intra and post operative effects

Document Type : Original Article

Authors

1 Obstetrics and gynecology,zagazig university,sharkia

2 Professor of Obstetrics and Gynecology Gynecology Faculty of Medicine - Zagazig University

3 lecturer of Obstetrics and Gynecology Gynecology Faculty of Medicine - Zagazig University

Abstract

Background: we hoped to see efficacy of tranexamic acid (TA) on reducing blood loss during elective cesarean delivery and its outcomes intra and postoperatively .Patient and Methods: We carried out a randomized, double-blind, placebo-controlled study over 156 females who underwent elective CS. patients were randomly selected to receive an intravenous infusion of TA (1 g/10 mL in 100 mL of lactated ringer before surgery. The primary outcome was estimated blood loss following CS. No demographic difference was observed between sets. Results: mean estimated blood loss was significantly lower in females treated with TA in comparison with females in control set (389.75±187.6 ml versus 724.45±214.5 ml, respectively; p1000 ml was significantly lower than in control set 3 [3.8%] versus 14 [17.9%], respectively. TA significantly reduced the need for additional uterotonics, females in control set versus TA set 8 [10.3%] versus 3 [3.8%], respectively. Conclusion: Maternal outcomes in TA set is better than control set , decrease the incidence of intra-operative atony , minor ooze and need for drain ,also decreased hospital stay significantly, Protected patients from hazards of blood transfusion , reduce incidence of atonic postpartum which in sever cases may lead to hysterectomy , maternal morbidity and mortality. No incidence of thromboembolic events .
fetal outcomes did not differ significantly.
Our results suggest that TA can be used safely and effectively to reduce Bleeding during CS.
Keywords: Tranexamic acid, cesarean delivery, bl00d lost, randomized control trial

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