Assessment of urinary kidney injury molecule-1 in children with iron deficiency anemia

Document Type : Original Article

Authors

1 Pediatric Department, Al-Ahrar Teaching Hospital, Sharkia, Egypt

2 Faculty of Medicine, Zagazig University, Department of Clinical Pathology, Sharkia, Egypt

3 Faculty of Medicine, Zagazig University, Department of Pediatrics, Sharkia, Egypt

Abstract

ABSTRACT
Background: Iron deficiency anemia (IDA) is a common type of anemia dur‌ing childhood that can cause tissue hypoxia which plays a major role in acute kidney injury (AKI).
Aim of the study: Assessment of urinary kidney injury molecule-1 in children with iron deficiency anemia for early detection of kidney injury.
Methods: This case control study was done at pediatric departmet of Zagazig uiversity hospitals where 23 children with IDA , 23 matched healthy controls were recruited , we assessed complete blood count (CBC), serum iron , total iron binding capacity, ferritin, serum levels of creatinine(Cr) , urea , sreum electrolytes sodium (Na), potassium(K), calcium (Ca), blood glucose levels, c-reactive protien (CRP). Urinary KIM-1 levels were measured and divided by urine creatinine .
Results: Our study showed no statistically significant differences in biochemical characteristics, serum creatinine and urea of the studied children of both case and control groups (P>0.05). Children with IDA had statistically significantly higher KIM-1/Cr ratio than control group (P

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