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Zagazig University Medical Journal
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Volume Volume 27 (2021)
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Ahmed, A., Zagloul, S., El-hady, H., Gomaa, A. (2021). Outcome of Decompensated Hepatitis C Virus Cirrhotic Patients Treated with Direct Acting Antiviral Drugs. Zagazig University Medical Journal, 27(1), 70-80. doi: 10.21608/zumj.2020.21566.1663
Amir Ahmed; Sahar Gouda Zagloul; Hoda Abdel-aziz El-hady; Ahmed Fathy Gomaa. "Outcome of Decompensated Hepatitis C Virus Cirrhotic Patients Treated with Direct Acting Antiviral Drugs". Zagazig University Medical Journal, 27, 1, 2021, 70-80. doi: 10.21608/zumj.2020.21566.1663
Ahmed, A., Zagloul, S., El-hady, H., Gomaa, A. (2021). 'Outcome of Decompensated Hepatitis C Virus Cirrhotic Patients Treated with Direct Acting Antiviral Drugs', Zagazig University Medical Journal, 27(1), pp. 70-80. doi: 10.21608/zumj.2020.21566.1663
Ahmed, A., Zagloul, S., El-hady, H., Gomaa, A. Outcome of Decompensated Hepatitis C Virus Cirrhotic Patients Treated with Direct Acting Antiviral Drugs. Zagazig University Medical Journal, 2021; 27(1): 70-80. doi: 10.21608/zumj.2020.21566.1663

Outcome of Decompensated Hepatitis C Virus Cirrhotic Patients Treated with Direct Acting Antiviral Drugs

Article 8, Volume 27, Issue 1, January 2021, Page 70-80  XML PDF (752.68 K)
Document Type: Original Article
DOI: 10.21608/zumj.2020.21566.1663
Authors
Amir Ahmed email orcid 1; Sahar Gouda Zagloul2; Hoda Abdel-aziz El-hady3; Ahmed Fathy Gomaa1
1Internal medicine,faculty of medicine,zagazig university,Egypt
2Internal Medicine Department, Faculty of Human Medicine, Zagazig University, Zagazig, Egypt
3Internal Medicine Dep. Zagazig Faculty of Medicine. Zagazig. Egypt
Abstract
Abstract
Background: All oral direct-acting antivirals (DAAs) effectively treat chronic hepatitis C infection (HCV) and widely used for patients with compensated cirrhosis. However, data regarding their safety and efficacy in patients with decompensated cirrhosis are insufficient .
Aim: to test efficacy, safety and outcome of DAAs in the treatment of decompensated HCV related cirrhotic patients (CTP-B).
Patients and Methods:prospective study among 62 chronic HCV cirrhotic patients, divided into two groups. Group I(the study group) included 32 patients with CTP-B treated for 12 weeks by sofosbuvir (SOF) 400 mg once daily plus Daclatasvir (DCV) 60 mg once daily plus Ribavirin (RBV) with initial dose 600 mg /day), while group II (the control group) included 30 patients with CTP-A treated by (SOF 400 mg once daily + DCV 60 mg once daily +RBV dosed according to body weight) for 12 weeks. According to the National Committee for control of viral hepatitis (NCCVH). Follow up after end of treatment (EOT) for 24weeks so the total period of the study 36 weeks
Results: cases achieved SVR in Group I: 93.75% and in group II:100%, Liver parameters were improved from baseline to 24 weeks after end of treatment. The most common adverse effects were anemia, no patients died by the end of the study, but one case 3.1% in group I stopped treatment due to severe complications.
Conclusion:Treatment with DAAs in patients with CTP-B is effective and safe, but patients remain at risk of life-threatening complications as HCC and liver-related morbidity.
Keywords
HCV; Sofosbuvir; Ribavirin; SVR; DAA
Main Subjects
Internal Medicine
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