ASSESSMENT OF THYROID FUNCTIONS IN INFANTS AND CHILDREN WITH HEART FAILURE DUE TO CONGENITAL HEART DISEASE

Mohamed, Samar Omar; El-Moghazy, Eman Mahmoud; Ahmed Ali, AL Shaymaa Ahmed; Ahmed, Hanan Samir

doi:10.21608/zumj.2020.17510.1555

ASSESSMENT OF THYROID FUNCTIONS IN INFANTS AND CHILDREN WITH HEART FAILURE DUE TO CONGENITAL HEART DISEASE

Document Type : Original Article

Authors

¹ Department of Pediatrics, Faculty of Medicine &ndash; Zagazig University, Egypt

² Department of Pediatrics, Faculty of Medicine – Zagazig University, Egypt

³ Department of Clinical pathology, Faculty of Medicine – Zagazig University, Egypt

10.21608/zumj.2020.17510.1555

Abstract

Background: Euthyroid Sick Syndrome is a common endocrinal change following any acute or chronic illness like those with heart failure which could be considered as a secondary adaptive change in which abnormalities in circulating thyroid hormone levels occur without pre-existing hypothalamic pituitary or thyroid gland dysfunction in the setting of a Non-Thyroidal Illness. Aim of the work: To explore that thyroid function may be altered in patients of heart failure and this may affect the severity and outcome of heart failure. Patients & Methods: The study was conducted in Pediatric cardiology unit, in Zagazig University hospital from April 2018 to January 2019. Results: our study we revealed that FT3 and FT4 were significantly lower among studied cases than their controls and TSH was higher among cases. In ECHO findings, the mean of EF% and FS% was lower among studied cases with positive correlation of FT3, FT4 with EF% and FS%, while TSH showed a negative correlation with EF and FS. Also our study showed that there was statistically significant relation between all thyroid functions and Ross classification for severity of heart failure, it was found that the mean of FT3 and FT4 in grade IV was lower than that of grade II and III, While the mean of TSH was higher in grade IV than grade II, III.
Conclusions: our study, thyroid function can be altered in pediatric heart failure and this alteration in thyroid function may be related to the severity of heart failure and worse outcome.

Keywords

Main Subjects