Protective effect of hesperidin modulates inflammatory response, oxidative stress status and blood pressure following renal artery stenosis in rats.

Khidr, Amany A.; Elshazly, Shimaa M.; El-fayoumy, Hassan; EL-Maraghy, Nabila

doi:10.21608/zumj.2020.27909.1813

Protective effect of hesperidin modulates inflammatory response, oxidative stress status and blood pressure following renal artery stenosis in rats.

Document Type : Original Article

Authors

¹ pharmacology, Pharmacy, zagazig university.

² pharmacology,pharmacy,zagazig university

³ Pharmacology,Pharmacy,zagazig university and Dean,pharmacy,Sinai university

⁴ Pharmacology,pharmacy,zagazig university and Vice dean,pharmacy,future university

10.21608/zumj.2020.27909.1813

Abstract

Background: Hesperidin (HES) is a natural occurring flavonoid extracted from citrus fruits that has been reported to possess many protective effects it has potent antioxidant and anti inflammatory activities. The aim of this study is to evaluate the effect of HES in attenuating renovascular hypertension (RVH) by using two kidney one clip (2K1C) renal artery stenosis (RAS) and repairing renal cell injury that occurred due to oxygen free radical.
Methods: Oral Supplementation of HES (50 mg/kg body weight) to renal artery stenosed rats.
Blood pressure was measured, oxidative stress markers and some involved inflammatory mediators tumor necrosis factor-α (TNF-α), cyclooxygenase-2 (COX-2) and prostaglandin-E2 (PG-E2).
Results: High blood pressure (BP) was attenuated and HES also down-regulated the expressions of TNF-α, COX-2 and PG-E2 in addition to ameliorate oxidative stress by increasing glutathione reductase (GSH) and decreasing malondialdehyde (MDA)..
Conclusion: These observations show that hesperidin exerts its anti-hypertensive activity up on altering inflammation and oxidation process that results in several cell and organ damage.

Keywords