STUDY OF THE POSSIBLE HEPATOPROTECTIVE EFFECT OF PROPOLIS AGAINST THE HEPATOTOXIC EFFECT OF ATORVASTATIN IN ALBINO RATS

Background: Liver injuries induced by various hepatotoxins have been recognized as a major toxicological problem for years. 3-Hydroxy-3-methyglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are widely used drugs to reduce cholesterol levels and prevent coronary heart disease. One of the adverse effects of statins is affection of the liver functions with increased transaminases levels. Propolis is collected by honeybees from various plant sources. It was found to have hepatoprotective activity. Aim: The present study evaluated the possible hepatoprotective effect of propolis against hepatotoxic effect of atorvastatin in albino rats. Methods: Propolis in doses of 50 and 100mg/kg were administered one hour before atorvastatin in doses of 20 and 80mg/kg daily, orally for one month. Hepatoprotective effect of propolis was evaluated by measuring levels of ALT and AST in the serum and SOD and CAT in the liver homogenate. The histopathological studies were also studied to support the biochemical parameters. Results: Atorvastatin in a dose of 20 and 80mg/kg produced dose-dependent, significant elevation of ALT, AST, SOD, CAT and hepatocyte degeneration. Administration of propolis 50 and 100mg/kg produced dose-dependent, significant reduction of the previous biochemical parameters and also prevented atorvastatin induced alterations in histoarcheticture of liver in a dose dependent manner.
Conclusion: Propolis protected the liver from the toxic effect of atorvastatin. The hepatoprotective effect of propolis may be due to its strong antioxidant activity.