Allogeneic injectable Platelet Rich Plasma improves neurotization index in a rat model

Mustafa, Mustafa Muhammed; Anani, Raafat Abd Ellatif; Mohamed Aly, Ahmed; Ibrahim Abdelhamid Mansy, Mohamed

doi:10.21608/zumj.2019.18582.1602

Allogeneic injectable Platelet Rich Plasma improves neurotization index in a rat model

Document Type : Original Article

Authors

¹ General surgey,faculty of medicine,zagazig university.

² Faculty of Medicine, Zagazig University, Department of plastic Surgery, Sharkia Egypt

³ Faculty of Medicine, Zagazig University, Department of Plastic and Microscopic Surgery, Sharkia Egypt

⁴ Faculty of Medicine, Zagazig University, Department of General Surgery, Sharkia Egypt

10.21608/zumj.2019.18582.1602

Abstract

Background: To detect the effect of injectable allogenic PRP in improvement of neurotization index in rat model.
Methods: This was Experimental and histopathological study that had included (21) .Sciatic nerve on both sides was cut transversely repaired microscopically. In all rats there was two groups Group (1): The left side (control group) we did Primary repair only but in Group (2): The Right side (PRP group): Activated PRP was injected under epineurium after primary repair
Results: There was a significant relationship between the count of nerve fibers distally in both groups and a Non-significant relationship proximally. In the control group G1 the neurotization index was (92.3 %) but in PRP group it was G2 (94.7%), and this statistics was considered valuable (P = .021). A reduction was noticed in the count of the new nerve ﬁbers distal to the repair in G1 (126.6) and G2 (138) compared with that of the proximal segments of the same groups (137and 145.67respectively which were statistically signiﬁcant in both groups (P = 0.00).
Conclusion: We found in our statistics a significant differences in the count of regenerated nerve fibers in (PRP group) distally and proximally and more in the distal count. PRP has aroused as a possible treatment option for peripheral nerve injury. Because of our results, PRP can be used as adjuvant therapy that helps in peripheral nerve regeneration in cases of primary nerve repair in humans.

Keywords

Main Subjects